MRCP UK EXAMINATIONS

Detailed explanation-1: -Early on in Guillain-Barré syndrome, the Schwann cells make new myelin to cover the neurons, which is called remyelination. But over time, the Schwann cells just can’t keep up, and there’s irreversible damage. Absence of myelin sheath means that nerve impulses become slow and sluggish.

Detailed explanation-2: -In most cases of GBS, the immune system damages the myelin sheath that surrounds the axons of many peripheral nerves; however, it also may also damage the axons themselves. As a result, the nerves cannot transmit signals efficiently and the muscles begin to lose their ability to respond to the brain’s commands.

Detailed explanation-3: -The demyelinating form of Guillain-Barre syndrome destroys the protective covering of the peripheral nerves (myelin sheath), preventing the nerves from transmitting signals to the brain. Guillain-Barre (gee-YAH-buh-RAY) syndrome is a rare disorder in which your body’s immune system attacks your nerves.

Detailed explanation-4: -Guillain-Barré syndrome (GBS) is an acute inflammatory polyneuropathy affecting the myelin-protein sheathing and the axons themselves to various degrees. Damage to these structures causes biomarkers to be released into the adjacent body fluid compartment.