A patient with acute myeloid leukemia (AML) is having hematopoietic stem cell transplantation (HSCT) with radiation ther-apy. Which complication will recognize the donors lymphocytes as foreign and set up reactions to attack the foreign host?

SURGERY

Please wait while the activity loads.
If this activity does not load, try refreshing your browser. Also, this page requires javascript. Please visit using a browser with javascript enabled.

If loading fails, click here to try again

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]

A patient with acute myeloid leukemia (AML) is having hematopoietic stem cell transplantation (HSCT) with radiation ther-apy. Which complication will recognize the donor’s lymphocytes as foreign and set up reactions to attack the foreign host?

A	Acute respiratory distress syndrome
B	Graft-versus-host disease
C	Remission
D	Bone marrow depression

Explanation:

Detailed explanation-1: -Hematopoietic cell transplantation (HCT) recipients may be at an increased risk of developing hypertension, diabetes, and dyslipidemia (referred to as cardiovascular risk factors [CVRFs]); and these factors can potentially increase the risk of cardiovascular disease (CVD).

Detailed explanation-2: -Allogeneic transplantation using stem cells or bone marrow from a tissue-matched brother or sister or unrelated donor produces cure rates of approximately 50 percent to 60 percent in patients with intermediate-risk AML.

Detailed explanation-3: -Post-transplant relapse of AML is associated with a high mortality rate, chiefly if relapse occurs early after transplantation, with an estimated 2-year overall survival of 9% for patients relapsing before D100 after HSCT.

Detailed explanation-4: -Infection. A major concern when a child undergoes a HSCT is infection. Graft Versus Host Disease. After the transplant, the child may develop graft versus host disease, or GVHD. Failure to Engraft. Conditioning Side Effects.

There is 1 question to complete.

MRCP UK EXAMINATIONS

NEUROLOGY

SURGERY