MRCP UK EXAMINATIONS

NEUROLOGY

SURGERY

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
Describe how natural killer (NK) cells serve as an important part of the body’s immune defense system.
A
The stroma is important in an indirect manner, in that it produces the colony-stimulating factors needed for hematopoiesis.
B
NK cells accumulate in the lymphoid tissues (especially spleen, lymph nodes, and tonsils), where they mature. When activated, they serve as potent killers of virus-infected and cancer cells. They also secrete chemical messenger proteins, called cytokines, to mobilize the T and B cells into action.
C
An increased number of band cells is sometimes called a left shift or shift to the left. A shift to the left indicates that more immature cells are present in the blood than normal.
D
Iron, vitamin B12, folic acid, pyridoxine, protein, and other factors are required. A deficiency of these factors during erythropoiesis can result in decreased red cell production.
Explanation: 

Detailed explanation-1: -A type of immune cell that has granules (small particles) with enzymes that can kill tumor cells or cells infected with a virus.

Detailed explanation-2: -Upon activation and recruitment to the site of infection, NK cells employ three main strategies to kill virally infected cells: the production of cytokines, the secretion of cytolytic granules, and the use of death receptor-mediated cytolysis [8].

Detailed explanation-3: -Natural killer cells (NK cells) are white blood cells that destroy infected cells and cancer cells in your body. NK cells are important fighters in your immune system. Your immune system protects you from harmful invaders, like pathogens (viruses, bacteria and parasites) and cancer cells.

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