NEUROLOGY
SURGERY
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Proliferative disorder of the myeloid stem cells
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Stem cell disease within the bone marrow
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Unicentric in origin and is initiated in a single node
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Heterogeneous group of cancers that originate from the neoplastic growth of lymphoid tissue
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Detailed explanation-1: -Is one of a related group of blood cancers known as “myeloproliferative neoplasms ‘’ (MPNs) in which cells in the bone marrow that produce the blood cells develop and function abnormally.
Detailed explanation-2: -There is no cure for ET, short of a hematopoietic stem cell transplant, but there are treatments available and with appropriate treatment, lifespan is usually normal. Specific treatment for ET is dependent upon risk of blood-clotting or bleeding episodes.
Detailed explanation-3: -Essential thrombocythemia can lead to a variety of potentially life-threatening complications, such as: Strokes. If a blood clot occurs in the arteries that supply the brain, it may cause a stroke. A mini stroke, also called a transient ischemic attack, is a temporary interruption of blood flow to part of the brain.
Detailed explanation-4: -The most common type of chemotherapy doctors use to treat ET is hydroxycarbamide. It is a tablet. There may be a small increase in risk of developing a leukaemia if you take hydroxycarbamide for a long time. Another type of chemotherapy is busulfan.
Detailed explanation-5: -Essential thrombocythemia may be caused by a person acquiring (not inheriting) a somatic genetic change in any of several genes, such as the JAK2 gene (most frequently), CALR gene, and rarely, the MPL, THPO, or TET2 gene. The reason why some people acquire genetic changes that cause the disease is unknown.