NEUROLOGY
SURGERY
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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What chemical agents may be responsible for producing bone marrow aplasia?
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Sepsis, trauma, cancer, shock, abruption placentae, toxins, and allergic reactions
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Answer may include the following:in an acute exacerbation of anemia, in the prevention of severe complications from anesthesia and surgery, in improving the response to infection, in the case of acute chest syndrome and multiorgan failure, in thwarting the evolution of a stroke or an acute neurologic defect, and in diminishing episodes of sickle cell crisis in pregnant women.
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Chemical agents potentially responsible for bone marrow aplasia include benzene and benzene derivatives such as airplane glue, paint remover, and dry-cleaning solutions. Certain toxic materials-such as inorganic arsenic, glycol ethers, plutonium, and radon-have also been implicated as potential causes.
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Chemical agents potentially responsible for bone marrow aplasia include benzene and benzene derivatives such as airplane glue, paint remover, and dry-cleaning solutions. Certain toxic materials-such as inorganic arsenic, glycol ethers, plutonium, and radon-have also been implicated as potential causes.
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Explanation:
Detailed explanation-1: -Benzene also causes a life-threatening disorder called aplastic anemia in humans and animals. This disorder is characterized by reduction of all cellular elements in the peripheral blood and in bone marrow, leading to fibrosis, an irreversible replacement of bone marrow.
Detailed explanation-2: -Aplastic Anemia (Pancytopenia) The International Agranulocytosis and Aplastic Anemia Study reported that 27% of their cases of aplastic anemia were likely drug-related. Penicillamine, gold, and carbamazepine were most commonly implicated (Table 63.2).
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