MRCP UK EXAMINATIONS

NEUROLOGY

SURGERY

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
Multiple myeloma
A
Proliferative disorder of the myeloid stem cells
B
Stem cell disease within the bone marrow
C
Malignant disease of the most mature form of B lymphocyte, the plasma cell
D
Unicentric in origin and is initiated in a single node
Explanation: 

Detailed explanation-1: -Multiple myeloma is a cancer of plasma cells. Normal plasma cells are found in the bone marrow and are an important part of the immune system. The immune system is made up of several types of cells that work together to fight infections and other diseases.

Detailed explanation-2: -Multiple myeloma cells are abnormal plasma cells (a type of white blood cell) that build up in the bone marrow and form tumors in many bones of the body. Normal plasma cells make antibodies to help the body fight infection and disease. As the number of multiple myeloma cells increases, more antibodies are made.

Detailed explanation-3: -Multiple myeloma (MM) and lymphoma are both cancers that affect cells in a person’s blood. MM is a cancer of plasma cells, while lymphoma is a cancer of lymphocytes. Both plasma cells and lymphocytes are types of white blood cell.

Detailed explanation-4: -Multiple myeloma (MM) is characterized by the malignant proliferation of plasma cells, terminally differentiated B-cells which under normal circumstances are responsible for the mass production of immunoglobulins.

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