MRCP UK EXAMINATIONS

RESPIRATORY

CYSTIC FIBROSIS

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
How does cf develop?
A
genetic distorted
B
allergic
C
Either A or B
D
None of the above
Explanation: 

Detailed explanation-1: -This condition is inherited in an autosomal recessive pattern, which means both copies of the gene in each cell have mutations. The parents of an individual with an autosomal recessive condition each carry one copy of the mutated gene, but they typically do not show signs and symptoms of the condition.

Detailed explanation-2: -It is widely known that mutations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene cause cystic fibrosis. Mutations in the gene result in lower levels of gene expression or the production of a defective protein by the same name.

Detailed explanation-3: -To have CF, a child must inherit two abnormal genes-one from each parent. The recessive CF gene can occur in both boys and girls because it is located on non-sex-linked chromosomes called autosomal chromosomes. CF is therefore called an autosomal recessive genetic disease.

There is 1 question to complete.