MRCP UK EXAMINATIONS

RESPIRATORY

CYSTIC FIBROSIS

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
Ivacaftor (Kalydeco) is a CFTR potentiator should be taken
A
on an empty stomach
B
with fat-containing food
C
Either A or B
D
None of the above
Explanation: 

Detailed explanation-1: -KALYDECO should always be taken with a fat-containing meal or snack because the fat helps the body absorb the medicine better. KALYDECO can be taken right before or right after a fat-containing meal or snack.

Detailed explanation-2: -It is believed that by binding to CFTR in the epithelial cell membrane, ivacaftor improves the function of both CFTR with gating mutations and CFTR with normal function [8, 15].

There is 1 question to complete.