MRCP UK EXAMINATIONS

Detailed explanation-1: -Cystic fibrosis is a common genetic disease within the white population in the United States. The disease occurs in 1 in 2, 500 to 3, 500 white newborns. Cystic fibrosis is less common in other ethnic groups, affecting about 1 in 17, 000 African Americans and 1 in 31, 000 Asian Americans.

Detailed explanation-2: -The disease occurs mostly in whites whose ancestors came from northern Europe, although it affects all races and ethnic groups. Accordingly, it is less common in African Americans, Native Americans, and Asian Americans. Approximately 2, 500 babies are born with CF each year in the United States.

Detailed explanation-3: -Introduction. Cystic fibrosis (CF) is an inherited autosomal recessive disease that threatens the patients’ whole life. Previous studies found that CF is more common in Caucasian population than in other populations [1].

Detailed explanation-4: -About 1 out of every 30 Caucasians, and 1 out of every 65 African Americans are carriers of a CF mutation. If both parents, are carriers for CF, a future child could get two mutations, (C) one from each parent and therefore have cystic fibrosis.

Detailed explanation-5: -Cystic fibrosis is the most common, life-limiting recessive genetic disorder in Caucasians. Approximately 30, 000 people have cystic fibrosis in the United States. One thousand new cases are diagnosed each year, with males and females affected in equal numbers.