MRCP UK EXAMINATIONS

Detailed explanation-1: -Dorothy Hansine Andersen was the first physician to identify cystic fibrosis as a disease and, together with her research team, created the first tests to diagnose it. She also spent nearly a decade examining glycogen storage disease, and studied cardiac malformations in great detail.

Detailed explanation-2: -1938: Dorothy Andersen, MD, publishes the first characterization of a disease mysteriously taking the lives of children: cystic fibrosis. 1955: The Cystic Fibrosis Foundation is formed by a group of concerned parents who are determined to save the lives of their children.

Detailed explanation-3: -It was during a routine autopsy on a child who was thought to have had celiac disease that Dr. Andersen noticed a lesion in the pancreas. Intrigued, she searched autopsy records and medical literature, and discovered a discrete disease pattern. She called this pattern cystic fibrosis.

Detailed explanation-4: -Cystic fibrosis (CF) was first recognized as a separate disease entity in 1938 when autopsy studies of malnourished infants distinguished a disease of mucus plugging of the glandular ducts, termed “cystic fibrosis of the pancreas, ‘’ from others with celiac syndrome (1).

Detailed explanation-5: -On Tuesday May 9, 1989, Cystic Fibrosis Canada-funded researcher, Dr. Lap-Chee Tsui, and his team at the Hospital for Sick Children in Toronto, together with Dr. Francis Collins at the University of Michigan, made history as they became the first to discover the gene responsible for cystic fibrosis.