AP PSYCHOLOGY

Detailed explanation-1: -So far, all antipsychotics block the dopamine-2 (D2) receptor in the brain, including recently available antipsychotics such as lurasidone, cariprazine and brexpiprazole. However large differences exist in binding strength to the D2 receptor that influence dosage ranges.

Detailed explanation-2: -Haloperidol and Other First-Generation Antipsychotics (FGA) Typical antipsychotics exert their action predominantly through dopamine D2 receptor antagonism.

Detailed explanation-3: -Dopamine antagonists They include metoclopramide and phenothiazines.

Detailed explanation-4: -First-generation or conventional antipsychotics are D2 antagonists, they lower dopaminergic neurotransmission in the four dopamine pathways. In addition, they can also block other receptors such as histamine-1, muscarinic-1 and alpha-1.