AP PSYCHOLOGY

Detailed explanation-1: -The mechanism by which clozapine exerts its effects involves the blocking of 5-HT2A/5-HT2C serotonin receptors and the D1-4 dopamine receptors, with the highest affinity for the D4 dopamine receptor.

Detailed explanation-2: -Clozapine is an atypical antipsychotic commonly used in the treatment of schizophrenia. Its efficacy is attributed to its antagonist actions at serotonin receptors (5-hydroxytryptamine receptor 2). The drug also antagonizes dopamine (D1 and D2) receptors and has significant antimuscarinic effects.

Detailed explanation-3: -Clozapine acts as an agonist at serotonin 2A receptors to counter MK-801-induced behaviors through a arrestin2-independent activation of Akt. Neuropsychopharmacology.

Detailed explanation-4: -Clozapine is a dopamine and serotonin antagonist (5HT2A) with a few unique differences compared to other SGAs. Clozapine has a high dissociation constant for D2, which is even higher than that of dopamine itself. Clozapine has much higher antagonistic activity on cortical and limbic dopamine D4 than D2 receptors.