AP PSYCHOLOGY

Detailed explanation-1: -The major findings are that schizophrenia is a highly polygenic disorder with a complex array of risk loci, many include genes implicated also in intellectual disability, autism spectrum disorders, bipolar disorder and major depressive disorder.

Detailed explanation-2: -Models of Genetic Transmission The monogenic model of schizophrenia was attractive for a variety of reasons, e.g., simplicity, a hope of discovering a corresponding, simple pathophysiological mechanism, and because it fitted into available theoretical options (i.e., recessive, dominant, with varying penetrance).

Detailed explanation-3: -The polygenic risk score (PRS) for schizophrenia, derived from very large numbers of weakly associated genetic markers, has been repeatedly shown to be robustly associated with schizophrenia in independent samples and also with other diseases and traits.

Detailed explanation-4: -A swath of chromosome 6 encompassing several genes known to be involved in immune function emerged as the strongest signal associated with schizophrenia risk in genome-wide analyses by the NIMH-funded Psychiatric Genomics Consortium over the past several years.