AP PSYCHOLOGY

Detailed explanation-1: -Parkinson’s disease is caused by a loss of nerve cells in the part of the brain called the substantia nigra. Nerve cells in this part of the brain are responsible for producing a chemical called dopamine.

Detailed explanation-2: -Parkinson’s disease is a progressive disorder that is caused by degeneration of nerve cells in the part of the brain called the substantia nigra, which controls movement. These nerve cells die or become impaired, losing the ability to produce an important chemical called dopamine.

Detailed explanation-3: -Insulin resistance and the hyperglycemia condition caused by T2DM lead to damage of dopaminergic neurons via several signaling pathways. In addition, inflammation, adipokine dysfunction and inappropriate energy metabolism by obesity, trigger the loss and degeneration of dopaminergic neurons.

Detailed explanation-4: -The degeneration of the dopaminergic neurons in the brain is thought to play a key role in the development of Parkinson’s disease. These neurons are vulnerable to degeneration because of their extensive branching and the large amounts of energy required to send nerve signals along this extensive network.

Detailed explanation-5: -Parkinson’s disease is a neurodegenerative disorder marked by the buildup of a misfolded protein, called alpha-synuclein, in brain cells. As more misshapen proteins clump together, they kill off brain cells called dopamine neurons, leaving behind large swaths of dead brain matter.