AP PSYCHOLOGY

Detailed explanation-1: -Our results suggest that between 29% and 46% of depressed patients fail to respond fully with antidepressant treatment of adequate dose and duration. In particular, although partial response appears to occur in 12% to 15% of the depressed patients studied, nonresponse is observed in 19% to 34% of this population.

Detailed explanation-2: -Nonadherence can account for up to 50% of treatment failures, around 125, 000 deaths, and up to 25% of hospitalizations each year in the United States. Typically, adherence rates of 80% or more are needed for optimal therapeutic efficacy.

Detailed explanation-3: -“It is a broad ranging concept affected in a complex way by the person’s physical health, psychological state, personal beliefs, social relationships and their relationship to salient features of their environment.”

Detailed explanation-4: -HRQOL is a multidimensional construct that consists of at least three broad domains – physical, psychological, and social functioning – that are affected by one’s disease and/or treatment. HRQoL is usually measured in chronic conditions and is frequently impaired to a great extent.