AP PSYCHOLOGY

Detailed explanation-1: -GABA (gamma-aminobutytic acid): Major inhibitory neurotransmitter. An undersupply can lead to tremors, seizures, and insomnia. Glutamate: Major excitatory neurotransmitter; involved in memory. Oversupply can overstimulate the brain leading to migraines (this is why some people avoid MSG in food).

Detailed explanation-2: -However, the GABA-deficiency theory of epilepsy is less convincing today. GABA agonists were found to intensify seizures in some rodent and human cases. Absence and other generalized seizures in humans often worsened when treated with GABA transaminase inhibitors such as gamma-vinyl-GABA.

Detailed explanation-3: -Lower-than-normal levels of GABA in the brain have been linked to schizophrenia, depression, anxiety, and sleep disorders.

Detailed explanation-4: -While a large number of neurotransmitters, ion channels, and other molecules regulate neuronal excitability, abnormalities in GABA, the major inhibitory neurotransmitter of the brain, perhaps represent the mechanism that is most frequently implicated in epilepsy.

Detailed explanation-5: -The most common excitatory neurotransmit-ter in the brain, glutamate, has been implicated in both the initiation and propagation of seizures as well as brain damage that can occur following prolonged or repeated seizures.