AP PSYCHOLOGY

Detailed explanation-1: -A person may develop tolerance to a drug when the drug is used repeatedly. For instance, when morphine or alcohol is used for a long time, larger and larger doses must be taken to produce the same effect.

Detailed explanation-2: -Cross-tolerance Long-term exposure to one drug often results in the development of tolerance to the effects of other structurally similar drugs in the same pharmacologic class. This phenomenon is termed cross-tolerance.

Detailed explanation-3: -Pharmacokinetic tolerance (dispositional tolerance) occurs because of a decreased quantity of the substance reaching the site it affects. This may be caused by an increase in induction of the enzymes required for degradation of the drug e.g. CYP450 enzymes. This is most commonly seen with substances such as ethanol.

Detailed explanation-4: -Cross-tolerance could occur. This is tolerance to other drugs in the same class. With certain classes of drugs, like opioids, tolerance can increase the risk of dependence, addiction, and overdose. When your body develops tolerance, using higher doses increases the risk of overdose.