BIOLOGICAL BASES OF BEHAVIOR
NEUROTRANSMISSION
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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block of internal sodium axon channels
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block of internal potassium axon channels
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blocking acetylcholine channels within local muscles
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inhibiting the action of neurotransmitter degraders
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Detailed explanation-1: -Local anesthetic drugs interfere with excitation and conduction by action potentials in the nervous system and in the heart by blockade of the voltage-gated Na channel.
Detailed explanation-2: -Mechanism of action of local anesthetics-LAs reversibly inhibit nerve transmission by binding voltage-gated sodium channels (Nav) in the nerve plasma membrane. Nav channels are integral membrane proteins, anchored in the plasma membrane.
Detailed explanation-3: -A class of drugs that act by inhibition of sodium influx through cell membranes. Blockade of sodium channels slows the rate and amplitude of initial rapid depolarization, reduces cell excitability, and reduces conduction velocity. An anti-anginal drug used for the treatment of chronic angina.
Detailed explanation-4: -Local anesthetics, antiarrhythmics, and anticonvulsants include both charged and electroneutral compounds that block voltage-gated sodium channels.
Detailed explanation-5: -Drugs which block sodium channels by blocking from the intracellular side of the channel include: Local anesthetics: lidocaine. Class I antiarrhythmic agents. Various anticonvulsants: phenytoin, oxcarbazepine (derivative of carbamazepine)