AP PSYCHOLOGY

Detailed explanation-1: -Local anesthetics potently block a potential insensitive potassium channel in myelinated nerve.

Detailed explanation-2: -Local anesthetics block nerve conduction by preventing the increase in membrane permeability to sodium ions that normally leads to a nerve impulse. Among anesthetics containing tertiary amine groups, the cationic, protonated form appears to be more active than the neutral form.

Detailed explanation-3: -Local anaesthetics stop the nerves in a part of your body sending signals to your brain. You won’t be able to feel any pain after having a local anaesthetic, although you may still feel some pressure or movement. It normally only takes a few minutes to lose feeling in the area where a local anaesthetic is given.

Detailed explanation-4: -Local anesthetics interrupt neural conduction by inhibiting the influx of sodium ions through channels or ionophores within neuronal membranes. Normally these channels exist in a resting state, during which sodium ions are denied entry.