AP PSYCHOLOGY

Detailed explanation-1: -Glutamate, on the other hand, is the main excitatory neurotransmitter in your brain, permitting the chemical messages to be carried from nerve cell to nerve cell. To have a properly functioning brain, a delicate balance must be maintained between the inhibitory effects of GABA and the excitatory effects of glutamate.

Detailed explanation-2: -An imbalance between excitation and inhibition has been a longstanding proposed mechanism regarding ictogenesis and epileptogenesis. This imbalance is related to increased extracellular glutamate in the brain and/or reduction in GABA concentrations, leading to excitotoxicity, seizures, and cell death.

Detailed explanation-3: -GABA-B receptors are present as autoreceptors that inhibit GABA release or heteroreceptors that reduce the release of glutamate, norepinephrine, serotonin, or dopamine.

Detailed explanation-4: -Abstract. gamma-Aminobutyric acid (GABA), the principal inhibitory neurotransmitter in the cerebral cortex, maintains the inhibitory tone that counterbalances neuronal excitation. When this balance is perturbed, seizures may ensue.

Detailed explanation-5: -If there is insufficient GABA in the brain, the neurons fire too often and too rapidly. This can lead to anxiety and insomnia. GABA dampens the transmission of nerve impulses between neurons, which has a calming influence.