AP PSYCHOLOGY

Detailed explanation-1: -Curare is an example of a non-depolarizing muscle relaxant that blocks the nicotinic acetylcholine receptor (nAChR), one of the two types of acetylcholine (ACh) receptors, at the neuromuscular junction.

Detailed explanation-2: -Curare, a selective skeletal muscle relaxant, has been used clinically to reduce shivering and as an anesthetic auxiliary in abdominal surgery. It is also widely used in animal experiments to block neuromuscular junction activity.

Detailed explanation-3: -Acetylcholine normally acts to stimulate muscle contraction; hence, competition at the neuromuscular junction by curare prevents nerve impulses from activating skeletal muscles. The major outcome of that competitive activity is profound relaxation (comparable only to that produced by spinal anesthesia).

Detailed explanation-4: -Botulinum neurotoxins cause paralysis by blocking acetylcholine release at neuromuscular junctions.

Detailed explanation-5: -Curare has long been regarded as a typical competitive antagonist of acetylcholine (ACh) at the vertebrate neuromuscular junction.