AP PSYCHOLOGY

Detailed explanation-1: -But at a basic level, brain proteins fail to function as usual. This disrupts the work of brain cells, also called neurons, and triggers a series of events. The neurons become damaged and lose connections to each other. They eventually die.

Detailed explanation-2: -In Alzheimer’s disease, as neurons are injured and die throughout the brain, connections between networks of neurons may break down, and many brain regions begin to shrink. By the final stages of Alzheimer’s, this process-called brain atrophy-is widespread, causing significant loss of brain volume.

Detailed explanation-3: -The study shows that neurons carrying the form of apoE associated with increased risk of Alzheimer’s disease, apoE4, are particularly susceptible to these stressors. This excess apoE turns on the expression of MHC-I, marking these neurons for destruction. Meanwhile, neurons with lower levels of apoE remain unharmed.

Detailed explanation-4: -As Alzheimer’s worsens, people experience greater memory loss and other cognitive difficulties. Problems can include wandering and getting lost, trouble handling money and paying bills, repeating questions, taking longer to complete normal daily tasks, and personality and behavior changes.

Detailed explanation-5: -Unlike other forms of dementia, Alzheimer’s does not affect patients’ motor function until late stages of the disease.