GENERAL HISTOLOGY

BONE

DEVELOPING BONE

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
During intramembranous ossification, which of the following is the first step:
A
osteoblasts lay down osteoid and it undergoes calcification
B
woven bone and surrounding periosteum form
C
lamella bone replaces wove bone as compact and spongy bone form
D
ossification centers form with mesenchyme (that differentiates into osteoblasts)
Explanation: 

Detailed explanation-1: -This process involves the direct conversion of mesenchyme to the bone. It begins when neural crest-derived mesenchymal cells differentiate into specialized, bone-forming cells called osteoblasts. Osteoblasts group into clusters and form an ossification center.

Detailed explanation-2: -1 – Intramembranous Ossification: Intramembranous ossification follows four steps. (a) Mesenchymal cells group into clusters, differentiate into osteoblasts, and ossification centers form. (b) Secreted osteoid traps osteoblasts, which then become osteocytes. (c) Trabecular matrix and periosteum form.

Detailed explanation-3: -The direct conversion of mesenchymal tissue into bone is called intramembranous ossification. This process occurs primarily in the bones of the skull. In other cases, the mesenchymal cells differentiate into cartilage, and this cartilage is later replaced by bone.

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