GENERAL HISTOLOGY

Detailed explanation-1: -Endochondral ossification is the process by which bone tissue is formed in early fetal development. It begins when MSCs start to produce a cartilage template of long bones, such as the femur and the tibia, upon which bone morphogenesis occurs.

Detailed explanation-2: -Endochondral ossification occurs at two distinct sites in the vertebrate long bone – the primary (diaphyseal) and the secondary (epiphyseal) sites of ossification. Bone development initiates at the primary site.

Detailed explanation-3: -Endochondral ossification involves the replacement of hyaline cartilage with bony tissue. Most of the bones of the skeleton are formed in this manner. These bones are called endochondral bones. In this process, the future bones are first formed as hyaline cartilage models.

Detailed explanation-4: -All of the bones of the body, except for the flat bones of the skull, mandible, and clavicles, are formed through endochondral ossification.