GENERAL HISTOLOGY

Detailed explanation-1: -Plasma cells are differentiated B-lymphocyte white blood cells capable of secreting immunoglobulin, or antibody. These cells play a significant role in the adaptive immune response, namely, being the main cells responsible for humoral immunity.

Detailed explanation-2: -Immunoglobulins are synthesized by a type of lymphocyte called a B cell, and are initially expressed as transmembrane proteins on the surface of each B cell, where they are termed surface immunoglobulin M (surface IgM). (A small amount of a surface immunoglobulin called IgD is also expressed by B cells.)

Detailed explanation-3: -Immunoglobulins are molecules produced by activated B cells and plasma cells in response to exposure to antigens. Upon antigen exposure, these molecules are secreted allowing the immune system to recognize and effectively respond to a myriad of pathogens.

Detailed explanation-4: -The plasma cells and medium-sized lymphocytes, which synthesize immunoglobulins, were localized predominantly in the interstitial connective tissue and ocasionally in the medulla, both near blood vessels.

Detailed explanation-5: -Plasma cells are immune cells that can migrate out of blood vessels into connective tissue. They are mature B-lymphocytes that produce large quantities of antibodies.