GENERAL HISTOLOGY

Detailed explanation-1: -The adrenal gland endocrine system includes the adrenal glands and pituitary gland. Signals from the pituitary gland stimulate the adrenal glands’ production of cortisol. Cortisol levels are sensed by the pituitary gland. Too much of the hormone cortisol in your body causes Cushing syndrome.

Detailed explanation-2: -The most common cause of Cushing’s syndrome is the long-term, high-dose use of the cortisol-like glucocorticoids. These medicines are used to treat other medical conditions, such as asthma link, rheumatoid arthritis link, and lupus link. Glucocorticoids are often injected into a joint to treat pain.

Detailed explanation-3: -Cushing disease occurs when a benign tumor in the pituitary gland causes the pituitary gland to produce too much ACTH, the hormone responsible for cortisol production. Too much ACTH in the body causes the adrenal glands to produce cortisol in high levels.

Detailed explanation-4: -Many of the clinical findings in Cushing’s syndrome are very common and have many more likely potential causes. Nearly all patients with the syndrome are obese, primarily in the trunk, due to stimulation of appetite and the effect of glucocorticoids to promote deposition of visceral fat.

Detailed explanation-5: -The 24-hour urinary cortisol test measures the amount of cortisol being produced within the urine over the course of an entire day. Levels higher than 50-100 micrograms per day in an adult suggest the presence of Cushing’s syndrome.