ENDOCRINE SYSTEM
THYROID FOLLICULAR CELL
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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MET oncogene is predominantly present in
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Medullary ca
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Papillary ca
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Follicular ca
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Hurthle cell ca
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Explanation:
Detailed explanation-1: -The main known genetic causes of thyroid cancer include point mutations in the BRAF, RAS, TERT, RET, and TP53 genes and the fusion genes RET/PTC, PAX8/PPAR-7, and NTRK.
Detailed explanation-2: -The MET (c-Met encoding) gene is located on human chromosome 7 (7q21-q31), includes 21 exons and 20 introns, and encodes a protein that is approximately 120 kDa in size [21]. The translated product is processed to form a heterodimer that is linked by the extracellular chain and the transmembrane chain.
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