GENERAL HISTOLOGY

Detailed explanation-1: -The most common laboratory findings demonstrate elevated thyroid-stimulating hormone (TSH) and low thyroxine (T4) levels, coupled with increased antithyroid peroxidase (anti-TPO) antibodies.

Detailed explanation-2: -Patients with Hashimoto thyroiditis have antibodies to various thyroid antigens, the most frequently detected of which include anti-thyroid peroxidase (anti-TPO), antithyroglobulin (anti-Tg), and to a lesser extent, TSH receptor-blocking antibodies (TBII).

Detailed explanation-3: -Thyroid peroxidase antibodies (TPO). These antibodies can be a sign of: Hashimoto disease, also known as Hashimoto thyroiditis. This is an autoimmune disease and the most common cause of hypothyroidism. Hypothyroidism is a condition in which the thyroid doesn’t make enough thyroid hormones.

Detailed explanation-4: -The presence of TPO antibodies in your blood suggests that the cause of thyroid disease is an autoimmune disorder, such as Hashimoto’s disease or Graves’ disease. In autoimmune disorders, your immune system makes antibodies that mistakenly attack normal tissue.

Detailed explanation-5: -Values above 9.0 IU/mL generally are associated with autoimmune thyroiditis, but elevations are also seen in other autoimmune diseases.