GENERAL HISTOLOGY

Detailed explanation-1: -Hepatotoxicity. Propylthiouracil has been associated with transient, asymptomatic elevations in serum aminotransferase levels, typically during the first 3 months of therapy. These elevations are rarely clinically significant and usually resolve even with continuation of therapy.

Detailed explanation-2: -Propylthiouracil (PTU) is commonly prescribed for patients with hyperthyroidism. PTU, however, can induce liver injury, ranging from mild asymptomatic elevation of aminotransferases to acute liver failure (ALF).

Detailed explanation-3: -Druginduced liver injury has been reported in 0.03% to 0.5% of patients taking antithyroid drugs. The use of PTU has been associated to severe, potentially fatal, liver disease while MMI has been associated more with inflammation of the gall bladder tract (cholestatic disease). Again, these reaction are very rare.

Detailed explanation-4: -Common chemicals that can cause liver damage include the dry cleaning solvent carbon tetrachloride, a substance called vinyl chloride (used to make plastics), the herbicide paraquat and a group of industrial chemicals called polychlorinated biphenyls.