GENERAL HISTOLOGY

EXCRETORY SYSTEM

KIDNEY

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
Which of the following are typical clinical signs of ADPKD?
A
Unilateral kidney enlargement
B
Bilateral kidney enlargement
C
Hypertension
D
Cataracts
Explanation: 

Detailed explanation-1: -Hypertension is a common early finding in ADPKD, occurring in 50 to 70 percent of cases before any significant reduction in glomerular filtration rate (GFR), with an average age onset of 30 years [1-3].

Detailed explanation-2: -ADPKD is characterized by the progressive development of bilateral renal cysts, resulting in urine concentration defects, enlargement of the kidney volume due to cystic formations, hypertension, hematuria, acute and chronic pain, cyst and urinary tract infections, and loss of renal function [6, 7].

Detailed explanation-3: -ADPKD can increase blood pressure in two main ways: 1) by altering the lining of your blood vessels, and 2) by activating hormones that control blood pressure. The faulty genes that cause ADPKD (PKD1 and PKD2) are not only important for your kidneys: they’re also found in the lining of your blood vessels.

Detailed explanation-4: -Edema in your legs, feet, ankles, hands, or face. Swelling, or edema, can occur because damaged kidneys are unable to get rid of extra fluid and salt in the body. Muscle cramping. A lack of appetite. Nausea and vomiting. Headaches and an inability to focus. Higher blood pressure. Peeing more. Drowsiness and sleep problems. More items •26-Aug-2022

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