GENERAL HISTOLOGY

EXCRETORY SYSTEM

KIDNEY

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
Why should the organs for transplants be removed quickly and kept cold?
A
Because, otherwise, they would start to smell.
B
Because, otherwise, they would be unhealthy.
C
Because, otherwise, they would deteriorate.
D
Because, otherwise, they would shrink.
Explanation: 

Detailed explanation-1: -As soon as an organ is removed from the body, the individual cells it is made from begin to die. Cooling helps slow the process as it reduces the metabolic rate of the cells.

Detailed explanation-2: -At higher temperatures (8°C to 12°C), organ function is maintained to a greater extent [11, 12]. However, at temperatures above 12°C the higher metabolic demand for oxygen leads to irreversible hypoxic injury and thus significantly impairs organ function.

Detailed explanation-3: -Unfortunately, there’s a major problem with cryopreservation: No one has been able to figure out how to bring tissues or organs back from the vitrified state without damaging them during reheating, explained Bischof. During the rewarming process, ice crystals form, resulting in major damage that makes them unusable.

Detailed explanation-4: -The cooling to adequate temperatures of some organs and tissues destined for transplantation reduces that enzyme activity and thus lessens the natural decomposition process. By the same rationale, the cooling reduces the metabolic work of cells and prevents degradation of their own structures to obtain energy.

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