GENERAL HISTOLOGY

Detailed explanation-1: -Langerhans cells play an important role in the skin’s response to foreign substances and contribute to such things as the development of rashes when an animal is exposed to irritating materials. Merkel cells are specialized cells associated with the sensory organs in the skin.

Detailed explanation-2: -Function. In skin infections, the local Langerhans cells take up and process microbial antigens to become fully functional antigen-presenting cells. Generally, tissue-resident macrophages are involved in immune homeostasis and the uptake of apoptotic bodies.

Detailed explanation-3: -Dendritic cells are present in those tissues that are in contact with the external environment, such as the skin (where there is a specialized dendritic cell type called the Langerhans cell) and the inner lining of the nose, lungs, stomach and intestines. They can also be found in an immature state in the blood.