GENERAL HISTOLOGY

Detailed explanation-1: -Most alcohol is broken down, or metabolised, by an enzyme in your liver cells known as alcohol dehydrogenase (ADH). ADH breaks down alcohol into acetaldehyde, and then another enzyme, aldehyde dehydrogenase (ALDH), rapidly breaks down acetaldehyde into acetate.

Detailed explanation-2: -Alcohol is metabolized by several processes or pathways. The most common of these pathways involves two enzymes-alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH). These enzymes help break apart the alcohol molecule, making it possible to eliminate it from the body.

Detailed explanation-3: -First, ADH metabolizes alcohol to acetaldehyde, a highly toxic substance and known carcinogen. Then, acetaldehyde is further metabolized down to another, less active byproduct called acetate, 1 which then is broken down into water and carbon dioxide for easy elimination.

Detailed explanation-4: -Reaction and Mechanism In its reaction, alcohol dehydrogenase uses zinc and NAD to facilitate the reaction. The function of zinc is to position the –OH group on the ethanol in a conformation that allows for the oxidation to occur. NAD then acts as a cosubstrate and performs the oxidation.

Detailed explanation-5: -Abstract. Alcohol dehydrogenase (ADH) and mitochondrial aldehyde dehydrogenase (ALDH2) are responsible for metabolizing the bulk of ethanol consumed as part of the diet and their activities contribute to the rate of ethanol elimination from the blood.