GENERAL HISTOLOGY

Detailed explanation-1: -To make room for haemoglobin, erythroblasts and reticulocytes progressively lose nuclei and organelles during maturation, which impairs the erythrocytes’ capacity to synthesise new proteins during their 120 days lifespan in the human bloodstream.

Detailed explanation-2: -Red blood cells have a limited lifespan because they don’t have a center membrane (nucleus). When a red blood cell travels through your blood vessels, it uses up its energy supply and only survives an average of 120 days.

Detailed explanation-3: -Losing the nucleus enables the red blood cell to contain more oxygen-carrying hemoglobin, thus enabling more oxygen to be transported in the blood and boosting our metabolism.

Detailed explanation-4: -As they mature in the bone marrow, they also lose their nucleus and organelles in order to increase space for oxygen. Due to this loss of a nucleus and other organelles, blood cells cannot repair themselves when damaged; this limits their lifespan to about 120 days.

Detailed explanation-5: -The average life cycle of a human RBC is approximately 120 days. Generally, by this point, the cell is worn out and damaged. RBCs pass through both the spleen and liver, where specialised immune cells called macrophages are found.