GENERAL HISTOLOGY

Detailed explanation-1: -Hepatocytes, the major parenchymal cells in the liver, play pivotal roles in metabolism, detoxification, and protein synthesis.

Detailed explanation-2: -Hepatocytes perform the task of detoxification of blood in one hand and also does the packaging and secretion of components such as lipid, protein and bile. In addition they take up nutrients from the blood stream.

Detailed explanation-3: -Hepatocytes synthesise and secrete bile into a system of tiny bile canaliculi which are present between adjacent hepatocytes. These canaliculi do not have a duct-like structure but consist merely of localised enlargements of the intercellular space between adjacent cells.

Detailed explanation-4: -Bile is secreted primarily by the hepatocytes into bile canaliculi. The bile canaliculus is formed by a groove of the lateral plasma membrane between two hepatocytes. With respect to bile secretion, the liver may be regarded as an epithelium transporting a variety of substrates from blood to bile.