GENERAL HISTOLOGY

Detailed explanation-1: -LDL particles are the primary carrier of cholesterol in the plasma and deliver cholesterol to peripheral cells via apolipoproteins B and E are also present in the liver so that particles formed by lipolysis of chylomicrons and VLDL are also cleared by the liver.

Detailed explanation-2: -Cholesterol is transported by complex particles, called lipoproteins, which have specific proteins on their surface. These proteins, called apolipoproteins, have an essential function in the metabolism of lipoproteins.

Detailed explanation-3: -Cholesterol is dynamically transported among membrane-bound organelles primarily by nonvesicular mechanisms. Sterol transfer proteins (STPs) bind cholesterol in their hydrophobic pockets and facilitate its transfer across the aqueous cytosol.

Detailed explanation-4: -Animal cells maintain cholesterol homeostasis by transporting cholesterol from one membrane to another. Cholesterol derived from low-density lipoprotein (LDL) is taken into cells through endocytosis mediated by LDL receptors (LDLRs) (1).

Detailed explanation-5: -High levels of LDL cholesterol raise your risk for heart disease and stroke. HDL (high-density lipoprotein) cholesterol, sometimes called “good” cholesterol, absorbs cholesterol in the blood and carries it back to the liver. The liver then flushes it from the body.