GENERAL HISTOLOGY

Detailed explanation-1: -As in all cells, the endoplasmic reticulum of hepatocytes is involved in translation and post-translational modification of proteins. The cytochrome P450 enzyme system is localized in the endoplasmic reticulum.

Detailed explanation-2: -Protein synthesis Hepatocytes manufacture their own structural proteins and intracellular enzymes. Synthesis of proteins is by the rough endoplasmic reticulum (RER), and both the rough and smooth endoplasmic reticulum (SER) are involved in secretion of the proteins formed.

Detailed explanation-3: -Rough endoplasmic reticulum (RER), smooth endoplasmic reticulum (SER), and Golgi complex are abundant in mammalian hepatocytes (see Figs.

Detailed explanation-4: -The endoplasmic reticulum (ER) is an essential organelle for protein and lipid synthesis in hepatocytes. ER homeostasis is vital to maintain normal hepatocyte physiology.

Detailed explanation-5: -Rough ER contains two integral membrane proteins, ribophorins I and II, that have molecular masses of 65 kDa and 63 kDa, respectively.