GENERAL HISTOLOGY

Detailed explanation-1: -Gastric acid stimulates secretin release, allowing movement into the duodenal lumen. Secretin causes an increase in pancreatic and biliary bicarbonate secretion and a decrease in gastric H+ secretion. Secretin stimulates the secretion of bicarbonate-rich pancreatic fluid.

Detailed explanation-2: -Secretin is the hormone that stimulates the release of bicarbonate from the pancreas. The small intestine secretes 4 types of hormones; cholecystokinin, secretin, gastric inhibitory peptide (GIP) as well as Motilin.

Detailed explanation-3: -Secretin is synthesized and secreted by S cells in the small intestine, and neurons in the brain. Secretin release is mainly stimulated by gastric acid delivered into the duodenal lumen. In addition, secretin is released by digested products of fat and protein.

Detailed explanation-4: -Cholecystokinin (CCK) and secretin are the peptide hormones that stimulate the production of pancreatic juice and bicarbonates within the alimentary canal.

Detailed explanation-5: -Regulation of Pancreatic Secretion Pancreatic juice is stimulated to flow in response to increases in the blood concentrations of two gastrointestinal hormones, secretin and cholecystokinin. Both hormones are liberated from the duodenal mucosa in response to different components of the luminal environment.