GENERAL HISTOLOGY

Detailed explanation-1: -Secretin stimulates the secretion of bicarbonate-rich pancreatic fluid.

Detailed explanation-2: -Secretin release is mainly stimulated by gastric acid delivered into the duodenal lumen. In addition, secretin is released by digested products of fat and protein.

Detailed explanation-3: -Control and Physiologic Effects of Secretin The principal target for secretin is the pancreas, which responds by secreting a bicarbonate-rich fluid, which flows into the first part of the intestine through the pancreatic duct.

Detailed explanation-4: -Secretin stimulates the secretion of a bicarbonate-rich pancreatic fluid (45). Secretin enters the blood stream or intestinal lumen and stimulates bicarbonate secretion (by interacting with pancreatic ductal cells), which neutralizes the pH of the gastric chyme upon entering the small intestine (83, 84).

Detailed explanation-5: -Secretin and CCK also control the production and secretion of bile. Secretin stimulates the flow of bile from the liver to the gallbladder. CCK stimulates the gallbladder to contract, causing bile to be secreted into the duodenum, as shown below.