GENERAL HISTOLOGY

MUSCLE

SKELETAL MUSCLE

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
The power stroke will occur when
A
ATP binds to the myosin head
B
The myosin head hydrolyses ATP into ADP and Pi
C
The myosin head releases Pi
D
The myosin head releases ADP
Explanation: 

Detailed explanation-1: -The power stroke occurs when ADP and phosphate dissociate from the myosin head. The power stroke occurs when ADP and phosphate dissociate from the actin active site. The power stroke occurs when Ca2+ binds the calcium head.

Detailed explanation-2: -According to the concept of Lymn and Taylor (1), the power stroke is driven by the release of the ATP-hydrolysis products ADP and phosphate from the active site.

Detailed explanation-3: -Step 4: The myosin head makes weak contact with the actin filament and a slight conformational change occurs on myosin that promotes the release of the inorganic phosphate.

Detailed explanation-4: -ADP is then dissociated from the myosin molecule, and the myosin head (the cross-bridge) remains firmly attached to actin. This condition persists until a new molecule of ATP binds to the myosin head, causing it to be released from the actin filament.

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