GENERAL HISTOLOGY

MUSCLE

SKELETAL MUSCLE

Question [CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
What is the function of Ca++ during a skeletal muscle contraction?
A
Connecting to nebulin
B
Connecting to tropomyosin
C
Connection to myosin
D
Connecting to troponin
Explanation: 

Detailed explanation-1: -In striated muscle, calcium causes a shift in the position of the troponin complex on actin filaments, which exposes myosin-binding sites (Fig. 2A). Myosin bound by ADP and inorganic phosphate (Pi) can then form cross-bridges with actin, and the release of ADP and Pi produces the power stroke that drives contraction.

Detailed explanation-2: -When calcium binds to troponin, the troponin changes shape, removing tropomyosin from the binding sites. The sarcoplasmic reticulum stores calcium ions, which it releases when a muscle cell is stimulated; the calcium ions then enable the cross-bridge muscle contraction cycle.

Detailed explanation-3: -Abstract. Calcium triggers contraction by reaction with regulatory proteins that in the absence of calcium prevent interaction of actin and myosin.

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