GENERAL HISTOLOGY

Detailed explanation-1: -Abstract. Intracellular acidosis due mainly to lactic acid accumulation has been regarded as the most important cause of skeletal muscle fatigue.

Detailed explanation-2: -Adenosine triphosphate (ATP) is the sole fuel for muscle contraction. During near maximal intense exercise the muscle store of ATP will be depleted in < 1s, therefore, to maintain normal contractile function ATP must be continually resynthesized.

Detailed explanation-3: -Without ATP, myosin heads are unable to release from the actin filaments and remain tightly bound to them (a protein complex called actomyosin). As a result, all the muscles in the body become rigid and are unable to move, a state known as rigor mortis.