AP PSYCHOLOGY

Detailed explanation-1: -A subsequent study analyzing gene expression in specific brain regions of patients with schizophrenia reported SELENBP1 upregulation in the prefrontal cortex (PFC) (7). Diagnostic symptoms of schizophrenia include negative symptoms characterized by social withdrawal, apathy, and emotional blunting (8, 9).

Detailed explanation-2: -2.The Mesocortical Pathway Decreased dopamine in the mesocortical projection to the dorsolateral prefrontal cortex is postulated to be responsible for negative and depressive symptoms of schizophrenia.

Detailed explanation-3: -Negative symptoms in schizophrenia have been associated with structural and functional changes in the prefrontal cortex. They often persist after treatment with antipsychotic medication which targets, in particular, the ventral striatum (VS).

Detailed explanation-4: -Dopamine in the prefrontal cortex of the brain plays a role in almost all aspects of high order cognition, including attention and behavioral flexibility. It’s also implicated in motivational and cognitive deficits of brain illnesses such as schizophrenia, addiction and attention-deficit/hyperactivity disorder.