ANIMAL PHYSIOLOGY
CHEMICAL SIGNALS
|
Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
|
|
|
cause ATP to form cAMP
|
|
|
add a phosphate to a kinase
|
|
|
remove a phosphate from a kinase
|
|
|
attract a ligand
|
Detailed explanation-1: -Studies of chemical mechanisms in adenylyl cyclases (AC) are justified by an importance of the enzyme-catalyzed conversion of adenosine triphosphate (ATP) to cyclic adenosine monophosphate (cAMP).
Detailed explanation-2: -As shown in Figure 22-2, adenylyl cyclase forms cAMP by creating a cyclic phosphodiester bond with the -phosphate group of ATP, with the concomitant release of pyrophosphate, which provides energy for the reaction.
Detailed explanation-3: -When adenylyl cyclase is activated, it catalyses the conversion of ATP to cyclic AMP, which leads to an increase in intracellular levels of cyclic AMP.
Detailed explanation-4: -Adenylyl cyclase is a membrane-bound enzyme that catalyzes the conversion of ATP to cAMP. [1] cAMP, an intracellular second messenger, activates protein kinase A by dissociating its regulatory subunit from the catalytic subunit.