LABORATORY REVIEW
ENZYME CATALYSIS
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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All the alcohol dehydrogenase molecules are bound to acetaldehyde molecules.
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At high concentrations of acetaldehyde, the activation energy of the reaction increases.
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At high concentrations of acetaldehyde, the activation energy of the reaction decreases.
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The enzyme is no longer specific for acetaldehyde.
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At high concentrations of acetaldehyde, the change in free energy of the reaction decreases.
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Detailed explanation-1: -In the presence of alcohol dehydrogenase, the conversion of acetaldehyde to ethanol increases as the concentration of acetaldehyde is increased. Eventually, the rate of the reaction reaches a maximum, after which point further increases in the concentration of acetaldehyde have no effect.
Detailed explanation-2: -Acetaldehyde Dehydrogenase (CoA-Acetylating) It was then discovered in the strictly anaerobic bacterium Clostridium kluyveri [135]. The enzyme is responsible for the conversion of acetyl-coenzyme A (acetyl-CoA) to acetaldehyde that is eventually converted to ethanol.
Detailed explanation-3: -The enzyme alcohol dehydrogenase (ADH) metabolizes the ethanol (that’s the type of alcohol in alcohol) into toxic acetaldehyde. From there the liver enzyme aldehyde dehydrogenase (ALDH) metabolizes acetaldehyde into acetate, a less toxic compound that breaks down into water and carbon dioxide.
Detailed explanation-4: -The NAD Cofactor Alcohol dehydrogenase uses two molecular tools to convert ethanol to acetaldehyde. The first is a zinc atom which is used to hold and position the alcohol group on ethanol. The second is a large NAD cofactor, which actually performs the reaction.
Detailed explanation-5: -Most of the ethanol in the body is broken down in the liver by an enzyme called alcohol dehydrogenase (ADH), which transforms ethanol into a toxic compound called acetaldehyde (CH3CHO), a known carcinogen.