ANIMAL PHYSIOLOGY
CHEMICAL SIGNALS
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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Theyexhibit density-dependent inhibition when growing in culture
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Theymust be attached to a substrate to divide in culture
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Theyevade the normal controls that trigger programmed cell death
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Theystop dividing in culture when growth factors are depleted
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Detailed explanation-1: -They evade the normal controls that trigger programmed cell death. They exhibit density-dependent inhibition when growing in culture.
Detailed explanation-2: -It also plays an important role in cancer.” One purpose of apoptosis is to eliminate cells that contain potentially dangerous mutations. If a cell’s apoptosis function is not working properly, the cell can grow and divide uncontrollably and ultimately create a tumor.
Detailed explanation-3: -Normal cells follow a typical cycle: They grow, divide and die. Cancer cells, on the other hand, don’t follow this cycle. Instead of dying, they multiply and continue to reproduce other abnormal cells. These cells can invade body parts, such as the breast, liver, lungs and pancreas.
Detailed explanation-4: -Cancer cells employ various means of preventing cell death including deregulation of the intrinsic apoptosis pathway. Upregulation of the anti-apoptotic BCL-2 proteins and loss of pro-apoptotic BH3 proteins has been observed in many cancers [34, 35].
Detailed explanation-5: -Cancer cells can ignore the signals that tell them to self destruct. So they don’t undergo apoptosis when they should. Scientists call this making cells immortal.