AP BIOLOGY

Detailed explanation-1: -The liver metabolises a wide range of drugs the end result being to produce water soluble compounds which can be excreted in the bile. This results from phase 1 reactions mediated by cytochrome p450 including oxidation, reduction and hydrolysis reactions.

Detailed explanation-2: -The liver can actively secrete ionized drugs with a molecular weight greater than 300 g/mol into bile, from where they reach the digestive tract and are either eliminated in feces or reabsorbed as part of the enterohepatic cycle.

Detailed explanation-3: -One of the main functions of the liver is to break down substances that we take by mouth, including medications, dietary supplements.

Detailed explanation-4: -Phase I metabolism involves functionalization reactions. Phase II drug metabolism is a conjugation reaction.