AP BIOLOGY

Detailed explanation-1: -The enzyme uricase (urate oxidase) can metabolize uric acid to highly soluble 5-hydroxyisourate that is further degraded to allantoic acid and ammonia, easily excreted by the kidneys.

Detailed explanation-2: -Uric acid (UA) is the end product of the metabolic pathway for purines, the main constituents of nucleotides. The pathway of UA generation is shown in Figure 1. Briefly, inosine monophosphate (IMP) is derived from de novo purine synthesis and from purine salvage.

Detailed explanation-3: -Purine nucleotide degradation refers to a regulated series of reactions by which human purine ribonucleotides and deoxyribonucleotides are degraded to uric acid in humans. Two major types of disorders occur in this pathway.

Detailed explanation-4: -Uric acid is a product of purine metabolism generated during the breakdown of nucleic acids (DNA and RNA) and ATP, and uric acid can also be generated from proteins.

Detailed explanation-5: -What is uric acid? Uric acid is the end product of purine (protein) metabolism or oxidation in the body, it is produced by the breakdown of purines (the constituent molecules of DNA and RNA) and is usually discarded from the body, by the kidney.