AP BIOLOGY

Detailed explanation-1: -Osteoclasts are large, multinucleated cells that are the primary bone-resorbing cells. They are hematopoietic in origin and are formed by fusion of mononuclear precursors in the marrow.

Detailed explanation-2: -Osteoclasts are the cells that degrade bone to initiate normal bone remodeling and mediate bone loss in pathologic conditions by increasing their resorptive activity. They are derived from precursors in the myeloid/monocyte lineage that circulate in the blood after their formation in the bone marrow.

Detailed explanation-3: -Osteoclasts are involved in bone resorption that contributes to bone remodelling in response to growth or changing mechanical stresses upon the skeleton. Osteoclasts also participate in the long-term maintenance of blood calcium homeostasis.

Detailed explanation-4: -Osteoblasts are bone-forming cells, whereas osteoclasts are bone destroying cells. Bones in our bodies are remodeled throughout our lives, which is accomplished by the concerted actions of osteoclasts and osteoblasts.

Detailed explanation-5: -Osteoblasts, osteocytes and osteoclasts are the three cell types involved in the development, growth and remodeling of bones. Osteoblasts are bone-forming cells, osteocytes are mature bone cells and osteoclasts break down and reabsorb bone. There are two types of ossification: intramembranous and endochondral.