BIOCHEMISTRY
ENZYMES AND METABOLISM
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Question
[CLICK ON ANY CHOICE TO KNOW THE RIGHT ANSWER]
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There will likely be no change in the shape and function of the enzyme.
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The enzyme will most likely fold in a way that makes its shape incompatible with the substrate and the enzyme will not function correctly.
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The enzyme will not be produced at all.
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The enzyme will have an enhanced ability to bind with the substrate.
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Detailed explanation-1: -If a mutation occurs in a DNA sequence that codes for an enzyme, what is the most likely result? The enzyme will most likely fold in a way that makes its shape incompatible with the substrate and the enzyme will not function correctly.
Detailed explanation-2: -If a mutation occurs on a segment of DNA that codes for an enzyme, what is most likely to happen to the enzyme? The enzyme shape is likely to change which will affect the active site and lead to a change of the enzyme activity.
Detailed explanation-3: -Mutations in enzymes can lead to serious or fatal disorders in humans and are the consequence of inherited abnormalities in the DNA of the affected individual. The mutation may be just as a single abnormal amino acid residue at a specific position in an enzyme encoded by a mutated gene.
Detailed explanation-4: -Some mutations increase expression of the enzyme upstream of the weak-link enzyme, pushing material through the dysfunctional metabolic pathway. Others enhance production of a co-substrate for a downstream enzyme, thereby pulling material through the pathway.
Detailed explanation-5: -The substrate binds to the enzyme by interacting with amino acids in the binding site. The binding site on enzymes is often referred to as the active site because it contains amino acids that both bind the substrate and aid in its conversion to product.